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Greening SPPS with Bachem

Bachem, the world’s largest peptides manufacturer, has announced some results of two studies it carried out with Novo Nordisk, seeking to make solid-phase peptide synthesis (SPPS) greener.

SPPS requires large volumes of solvents and the current gold standards, because of their excellent solubilisation and stability properties for reagents and resin swelling capabilities, are N-dimethylformamide (DMF), dichloromethane and N-methyl-2-pyrrolidone. All now face restrictions under REACH because of their hazardous nature.

Nippon Shokubai goes green

Nippon Shokubai has established a new Green Innovation department within the Innovation & Business Development division. This, the company said, will integrate sustainable projects with research planning and development organisations related to energy and resource use. Its key responsibilities are to develop:

* Manufacturing methods from bio-based raw materials of the firm’s core products of acrylic acid and ethylene oxide

* CO2 capture and conversion technology

* New technologies for ammonia manufacturing and utilisation

PFAS claims in Delaware settled

DuPont and the companies that used to be part of it, Chemours and Corteva, have reached a settlement with the Delaware Department of Justice. Under this, they are held responsible for decades of damage done to Delaware’s environment by per- and polyfluoroalkyl substances (PFASs).

The agreement has avoided a potential lawsuit for historic contamination by PFASs in Delaware, which remains DuPont’s headquarters. This had impacted waterways and groundwater located in each of the state’s three counties.

UK distributors hit by driver shortages

UK distributors hit by driver shortage The Chemical Business Association (CBA), which represents chemical distributors and logistics services providers in the UK, has again highlighted the chronic shortage of HGV drivers since Brexit. This, they said in a letter to the Secretaries of State for Transport and Business “has reached a critical point for the UK chemical supply chain”.

First non-animal allergy testing strategy approved

The Organisation for Economic Co-operation & Development (OECD) has approved the world’s first toxicology testing strategy without animal testing. This can now be used to test for skin sensitisation and any products that pass can be placed on the market.

The strategy, which consists of three ‘alternative’ methods, was jointly developed and validated over ten years by BASF and Givaudan, in partnership with various companies and scientific institutions, notably IIVS. It is claimed to have better predictivity for human allergy risks than traditional animal testing.

CEFIC: Increase in non-compliant article imports

According to an analysis by CEFIC of data reported through the EU’s Safety Gate, 2020 saw a steep increase in imports of hand sanitisers that were not compliant with the EU chemicals safety rules. These were either not marked as flammable or containing methanol, as required by EU Classification & Labelling rules, or had insufficient ethanol to kill viruses, as required by the Biocides Regulation, CEFIC noted.

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