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Greening SPPS with Bachem

Bachem, the world’s largest peptides manufacturer, has announced some results of two studies it carried out with Novo Nordisk, seeking to make solid-phase peptide synthesis (SPPS) greener.

SPPS requires large volumes of solvents and the current gold standards, because of their excellent solubilisation and stability properties for reagents and resin swelling capabilities, are N-dimethylformamide (DMF), dichloromethane and N-methyl-2-pyrrolidone. All now face restrictions under REACH because of their hazardous nature.

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