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$1 billion peptide deal announced

CordenPharma has signed a multi-year agreement for the contract manufacture of a large-volume launch peptide at its former Roche facility in Boulder, Colorado. This will begin in 2023 and will potentially be worth about $1 billion, depending on actual production levels required. The customer has not been named and no further details are being disclosed.

Bachem signs follow-on contract

Bachem has signed a further work order with an unnamed customer for large volumes of peptides for a minimum total of CHF 1 billion from 2025 to 2029. This follows two previous large-volume contracts announced in September worth CHF 175 million in 2023-4. No further details will be disclosed.

Bachem acquires third Swiss site

Peptides giant Bachem has agreed to acquire an undeveloped site covering 155,000 m2 in Sisslerfeld, north-western Switzerland, from DSM in order to manage growing demand. It has already acquired the first plot and others will follow in time. Terms are not being disclosed.

Bachem automates SPPS

Bachem, the world market leader in peptides, has automated and digitalised one of its core business processes, solid-phase peptide synthesis (SPPS). The company describes this as the start of its journey to Industry 4.0. The process is described in detail on the company website (www.bachem.com/news/bachem-journey-to-industry-4-0/).

Bachem in oligonucleotide deal

Bachem has entered a strategic collaboration under which it will provide the infrastructure and expertise to implement Eli Lilly & Company’s novel manufacturing technology for oligonucleotide APIs. It will also supply R&D and production at its site in Bubendorf, Switzerland, to make GMP-grade material using this technology.

Greening SPPS with Bachem

Bachem, the world’s largest peptides manufacturer, has announced some results of two studies it carried out with Novo Nordisk, seeking to make solid-phase peptide synthesis (SPPS) greener.

SPPS requires large volumes of solvents and the current gold standards, because of their excellent solubilisation and stability properties for reagents and resin swelling capabilities, are N-dimethylformamide (DMF), dichloromethane and N-methyl-2-pyrrolidone. All now face restrictions under REACH because of their hazardous nature.

Bachem in Molecular Hiving deal

Bachem, the world’s largest producer of pharmaceutical peptides and ologonucleotides, has signed an exclusive licensing agreement with Japanese firm Jitsubo related to the latter’s liquid-phase peptide technology. Molecular Hiving. Financial terms were not disclosed. The two firms have already worked together on APIs and cosmetic peptides.

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